Aktuelle Therapieansätze der Sarkoidose

Abstract

Sarcoidosis represents a non-caseating, granulomatous disorder of unknown aetiology whose clinical manifestation is heterogeneous and frequently multisystemic. The portion of patients needing systemic treatment varies: though many patients may undergo spontaneous remission, organ-threatening courses demand systemic therapy. Corticosteroids are the first-line treatment option; however, disease´s progression and/or major corticosteroid side effects may require second- and third-line therapeutics. A current stepwise therapeutic algorithm to sarcoidosis that characterizes additive and alternative therapeutic agents is given in the following review.

Die Sarkoidose ist eine Multisystemerkrankung mit heterogenem Erscheinungsbild. Die Indikation zur Therapie ist abhängig von der Art und dem Schweregrad der Organbeteiligung: Einerseits gibt es hohe Spontanremissionsraten, andererseits erzwingen Organschäden eine systemische Therapie. Einen aktuellen Überblick über die verfügbaren Substanzen im Therapiealgorithmus der Sarkoidose gibt der folgende Beitrag.

Schlüsselwörter

Sarkoidose - Kortikosteroide - Antimetabolite - Tumor-Nekrose-Faktor α-Blocker

Key words

sarcoidosis - corticosteroids - antimetabolites - tumor necrosis factor α-inhibitors

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